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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12751 | RORγt agonist 1 | Others | |
RORγt agonist 1 is a potent, orally bioavailable agonist of RORγt(EC50 of 20.8 nM). | |||
T9623 | RORγt inverse agonist 13 | ROR | |
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. | |||
T4670 | SR0987 | ROR | |
SR0987 is a RORγt agonist, | |||
T62564 | RORγt inverse agonist 30 | ||
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist (IC50: 46 nM). Targeting the nuclear receptor RORγt is effective in the treatment of autoimmune diseases. | |||
T79470 | RORγt inverse agonist 31 | ROR | |
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (IC50) of 0.428 μM. It has demonstrated efficacy in mitigatin... | |||
T72252 | RORγt inverse agonist 14 | ROR | |
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. | |||
T36998 | 7β,27-dihydroxy Cholesterol | 7β,27-DHC,7β,27-dihydroxy Cholesterol | |
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res... |